Association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria.

The relationship between urinary tract infection caused by urease-producing bacteria and lithiasis due to struvite stones is well established in the literature. However, there is limited knowledge on whether non-urease producing bacteria can also promote crystallization. In our study, we analyzed the association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria, in 153 patients who underwent surgery for urinary stone. The collected samples were sent for crystallographic analysis and culture. Additionally, preoperatory urine culture was collected for combined evaluation with the previous data. Percutaneous nephrolithotomy was the most commonly performed approach (45.8%). Struvite stones were more frequently identified in women (90.3%). Among stones with positive cultures, except struvite, 45.5% were composed of calcium oxalate monohydrate. The difference between urine culture and stone culture was different in 24.8% of the cases. Among stones with positive cultures that did not contain struvite, 86.4% showed non-urease bacteria in their cultures and 47.1% of struvite stones also did not have urease-producing bacteria in their cultures (p < 0.021). Our findings suggest that there is an association between non-ureolytic bacteria and stones that are not composed of struvite.

Tratamento da osteonecrose dos maxilares associada aos bifosfonatos: revisão da literatura / Treatment of bisphosphonate related osteonecrosis of the jaw: literature review

A osteonecrose dos maxilares associada aos bifosfonatos(OAB) é uma condição que afeta pacientes que receberamtratamento com estes medicamentos. Sendo principalmenteutilizados no tratamento de neoplasias malignas ósseas, doençade Paget e mais comumente nos casos de osteoporose pósmenopausa.O mecanismo pelo qual os bifosfonatos promovemtal fenômeno ainda é desconhecido. O tipo de bifosfonato, a viade administração, bem como a duração do tratamento com essasdrogas parece ter relação direta com a incidência de OAB. Oobjetivo deste trabalho foi revisar alguns aspectos importantesdesta condição reforçando sua abordagem terapeutica.